Advances in Understanding Kingella kingae by Joseph W. St. Geme III

By Joseph W. St. Geme III

This ebook describes the turning out to be physique of data at the epidemiology, medical manifestations, transmission, pathogenesis, analysis, and remedy of Kingella kingae infectionsin childrens. moreover, it covers experimental equipment which have been built to check the microbiology, genetics, and virulence elements of K. kingae, details that gives the root for brand spanking new methods to remedy and prevention of K. kingae disease. With this content material in brain, excerpts from the publication should be of relevance for clinicians who take care of pediatric sufferers, for scientific microbiologists who're inquisitive about detecting organisms in medical specimens, and for scientists who're learning K. kingae in an attempt to strengthen novel pursuits for antimicrobial remedy and new ways to prevention.

First remoted within the Sixties through Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae was once principally neglected over the following 20 years as a human pathogen due to its unusual restoration from sufferers with affliction. although, in recent times K. kingae has been more and more famous as a clinically very important pathogen in youngsters, and is at the moment well-known because the prime reason behind osteoarticular infections in young ones in an increasing number of nations. study into this organism has grown vastly over the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of sickness.

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Kingae RTX toxin was discovered following the observation that introduction of K. kingae onto a cell monolayer resulted in cell rounding and lysis. A transposon library screen identified a locus with high homology to the Mbx locus in Moraxella bovis that is absent in the less pathogenic Kingella species K. oralis and K. denitrificans [35]. This locus also has high homology to RTX toxins in H. influenzae and N. meningitidis, suggesting that K. kingae acquired the rtx genes through horizontal gene transfer [35].

In the longitudinal study by Amit et al. 1 % of children were colonized at least twice. Among the children with K. kingae isolated on multiple visits, 90 % of strains isolated within 2 months of one another were genetically similar, whereas only 22 % of isolates identified greater than 5 months apart were genetically similar. These data demonstrate that carriage of specific strains is relatively transient in healthy children, lasting weeks to months. Strains that colonize the oropharynx may be replaced, and long-term carriage by a specific strain is rare.

Sena AC, Seed P, Nicholson B, Joyce M, Cunningham CK (2010) Kingella kingae endocarditis and a cluster investigation among daycare attendees. Pediatr Infect Dis J 29 (1):86–88. 0b013e3181b48cc3 30. Gene A, Garcia-Garcia JJ, Sala P, Sierra M, Huguet R (2004) Enhanced culture detection of Kingella kingae, a pathogen of increasing clinical importance in pediatrics. Pediatr Infect Dis J 23(9):886–888 31. Dubnov-Raz G, Scheuerman O, Chodick G, Finkelstein Y, Samra Z, Garty BZ (2008) Invasive Kingella kingae infections in children: clinical and laboratory characteristics.

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