Antimicrobial Resistance and Implications for the 21st by I.W. Fong, Karl Drlica

By I.W. Fong, Karl Drlica

This finished, up to date quantity defines the problems and provides capability strategies to the demanding situations of antimicrobial resistance. The bankruptcy authors are major overseas specialists on antimicrobial resistance between various micro organism, viruses together with HIV and herpes, parasites and fungi. The chapters discover the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance traces, scientific implications and implications on learn and shortage thereof, and prevention and destiny instructions.

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Additional resources for Antimicrobial Resistance and Implications for the 21st Century (Emerging Infectious Diseases of the 21st Century)

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Clin Infect Dis, 29, 462–463. , Etienne, J. , (2000), Characterization of isolates associated with emerging resistance to quinupristin/dalfopristin (Synercid) during a worldwide clinical program. Diagn Microbiol Infect Dis, 37, 57–62. Drlica, K. , (1997), DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev, 61, 377–392. , Soderstrom, M. , (1997), Duration of nasopharyngeal carriage of penicillin-resistant Streptococcus 38 J. A. Marco et al. pneumoniae: experiences from the South Swedish Pneumococcal Intervention Project.

2005) to assess trends of antimicrobial resistance in S. 3% of isolates had ciprofloxacin MICs of ≥4 mg/l. Trend analysis since 1994–1995 indicated that rates of resistance to β-lactams, macrolides, tetracyclines, trimethoprim– sulfamethoxazole (TMP–SMZ) and multiple drugs have either plateaued or have begun to decrease. Conversely, fluoroquinolone resistance among S. pneumoniae is becoming more prevalent. Ciprofloxacin MIC of ≥4 mg/l as an indicator of diminished fluoroquinolone activity, appeared to have occurred in the United States sometime during the 2-year period between the winters of 1999–2000 and 2001–2002.

Clin Infect Dis, 38, 787–798. , Martínez-Sanchis, A. , (2006), Impact of Initial antibiotic choice on mortality from pneumococcal pneumonia. Eur Respir J, 27, 1–10. Austrian, R. , (1964), Pneumococcal bacteremia with special reference to bacteremic pneumococcal pneumonia. Ann Intern Med, 60, 759–776. , International Pneumococcal Study Group, (2004), Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med, 170, 440–444. , Rubinstein, E.

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